Israel bombed a military position in Aleppo province late on Sunday, Syrian state media reported.
State news agency SANA quoted a military source as saying that the missile attack hit near a strategic air base.
"The Zionist enemy [Israel]... targeted with its missiles one of our military positions north of the Neirab military airport, but the damage was only material," the report said.
The Israeli military did not comment on the incident and rarely confirms strikes on Syrian positions.
Suspected Israeli air strikes have hit Syrian army positions near Damascus and in the central provinces of Homs and Hama in the past.
However, they rarely occur as far north as Aleppo.
Israel has repeatedly warned it will not tolerate the presence of archfoe Iran in Syria.
Tehran has dispatched military advisors to bolster Syrian President Bashar Al Assad's efforts to fight back a seven-year uprising threatening his rule, while Iran-backed forces, including Hezbollah, have been in the country fighting alongside the Assad forces.